As the current image (V4) is a a bit old, I've started with a clean install of Buster and I've run modified version of the Protoneer script (no bCNC, Chilipepper, etc) to install necessary software. So far, it all seems to work in so far as Laserweb4 starts and the serial port has no getty, console etc.
I was going to test the Pi I have with an old CNC shield and UNO but no level shifter so it will have to wait until Sunday when I have access to the laser (it's 60km away)

No changes were needed to the scripts except to exclude things I didn't want to install and to comment out some scripts that setup tries to run, but don't exist. I did find a minor problem with the setup of arduino software in that avrdude-autoreset referred to version 1.8.5 but the version installed is now 1.8.10.
Fingers crossed.